Penn State had one top 25 team, let's not go overboard here.
Also, Penn State played Bucknell home and home (or home and neutral) a ton while Paulsen was there. I'm sure our first home and home was a favor from that relationship.
If we can move into a solid road Q1/2 game every season, I'm sure we could start scheduling a few of these.
I'm also sure we're going to take at least 2 guarantee games (although, the payout for these isn't going to be as high next season, so it might not really be worth it unless it's relatively close -- hello Georgetown, hello Villanova).
edit: Our two guarantee games last year were UMD and TCU. UMD was Q1 road game, TCU turned out to be a Q2 road game. We got destroyed by both teams. The TCU game was especially not fun to watch. The problem with our scheduling isn't taking P5 games, it's taking way too many home games against NET 250+ teams.